Mast cell-dependent anorexia and hypothermia induced by mucosal activation of Toll-like receptor 7
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منابع مشابه
Mast cell-dependent anorexia and hypothermia induced by mucosal activation of Toll-like receptor 7.
Systemic viral infections produce a highly regulated set of responses in sickness behavior, such as fever, anorexia, and adipsia. Toll-like receptor (TLR)7, activated by viral RNA during infection, potently stimulates the innate and adaptive immune responses that aid in viral clearance. However, the physiological consequences of TLR7 activation have not been thoroughly studied. In these experim...
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Number of text pages: 34 Word and character counts: 10339 words and 56763 characters Abbreviation: Toll-like receptor (TLR), myeloid differentiation primary response gene 88 (MyD88), dexamethasone (DEX), intraperitoneally (i.p.), intranasally (i.n.), prostaglandin E2 (PGE2), cyclo-oxygenase (COX), chlorpheniramine maleate (CM), cimetidine (CIM), cromolyn Page 1 of 38 Articles in PresS. Am J Phy...
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We investigated the expression of a panel of Toll-like receptors (TLRs) and their functions in human eosinophils. Eosinophils constitutively expressed TLR1, TLR4, TLR7, TLR9, and TLR10 mRNAs (TLR4 greater than TLR1, TLR7, TLR9, and TLR10 greater than TLR6). In contrast, neutrophils expressed a larger variety of TLR mRNAs (TLR1, TLR2, TLR4, TLR6, TLR8 greater than TLR5, TLR9, and TLR10 greater t...
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OBJECTIVES To investigate the potential synergy of IL-7-driven T cell-dependent and TLR7-mediated B cell activation and to assess the additive effects of monocyte/macrophages in this respect. METHODS Isolated CD19 B cells and CD4 T cells from healthy donors were co-cultured with TLR7 agonist (TLR7A, Gardiquimod), IL-7, or their combination with or without CD14 monocytes/macrophages (T/B/mono;...
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Background: Myocardial dysfunction is one of the major complications in patients with sepsis where there is a relationship between the blood level of cytokines and the onset of myocardial depression. In many cases of sepsis, the presence of Lipopolysaccharide (LPS) has been established. LPS Binding Protein (LBP) bound endotoxin is recognized by CD14/toll-like receptor-4 (TLR4) complexes in inna...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
سال: 2008
ISSN: 0363-6119,1522-1490
DOI: 10.1152/ajpregu.00527.2007